明嘉靖年間，朝廷被嚴黨把持，內(nèi)部朝政腐敗，沿海倭寇橫行，明朝危在旦夕。南京城內(nèi)，南京總兵程肅之子程聞道天資聰慧、少年得志，本欲與青梅竹馬的郡王府郡主李蓁蓁喜結(jié)良緣，然而，這一文一武兩家的聯(lián)姻，卻引起了朝廷高官明德的恐懼。
于是，明德設(shè)計提拔程聞道的結(jié)拜弟兄高劍雄，并假傳圣旨將程聞道一家滅門。心存愧疚的高劍雄放了程聞道一條生路，但兩人從此結(jié)怨。重傷的聞道被少林僧人救回少林藥局救治，一段關(guān)于“禪、武、醫(yī)”的問道故事就此展開。
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